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KMID : 0858820140310040001
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Journal of Korean Society for Health Education and Promotion
2014 Volume.31 No. 4 p.1 ~ p.10
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The Effectiveness of Blood β-ketone Testing in Patients with Diabetic Ketosis: A Systematic Review & Meta-analysis
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Mo Jin-A
Jang Sun-Young
Bang Hee-Young
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Abstract
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Objectives: The effectiveness of Blood β-ketone testing by using self-monitoring strip on diabetic patients.
Methods: Clinical effectiveness of blood β-ketone testing was assessed through correlation with reference test that measured blood β-ketone value through gas chromatography or enzyme method, diagnostic accuracy, time taken for the test and time taken for confirmative diagnosis of diabetic ketosis by selecting literatures on researches that conducted this test on ketosis(suspected) patients or diabetic ketosis(suspected) patients. Each of the stages from literature search to application of selection standards and extraction of data were carried out independently by the Subcommittee along with 2 researchers.
Results: 7 reports were selected. β-ketone testing displayed high level of correlation in the range of r=0.92～0.99 with test using enzyme method as the reference standard. Regarding the diagnostic accuracy, sensitivity of 0.82, specificity of 0.74. The time taken for the test was 30seconds for the index test, which is shorter than reference standard test.
Conclusion: Blood β-ketone testing was assessed to be a safe and effective test to monitor ketosis and assess the level of risk of ketosis by measuring the blood β-ketone on ketosis patients and diabetic ketosis patients since it has high level of correlation with reference test and short period of testing.
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KEYWORD
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Diabetic Ketoacidosis, Ketosis, Electrochemical Techniques, Systematic Review, Meta Analysis
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